Publication Highlights
Modulators of Colitis and Colitis-associated Cancer (CAC)
Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn’s Disease.Journal of Clinical Medicine 2020, 9, 1360; doi:10.3390/jcm9051360
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x.
NoxO1 Controls Proliferation of Colon Epithelial Cells. Frontiers in Immunology 05/2018; 9;973, DOI:10.3389/fimmu.2018.00973
Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer. Frontiers in Immunology 01/2017; 8(44)., DOI:10.3389/fimmu.2017.00044
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cellular and Molecular Life Sciences 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn s and Colitis 02/2016; 10(8):jjw056., DOI:10.1093/ecco-jcc/jjw056
FTY720 Ameliorates Th1-Mediated Colitis in Mice by Directly Affecting the Functional Activity of CD4+CD25+ Regulatory T Cells. Journal of Immunology 2007 Feb 15;178(4):2458-68
Peer-Reviewed Publications
2020
Inflammation-Induced Mucosal KYNU Expression Identifies Human Ileal Crohn’s Disease. Journal of Clinical Medicine 2020, 9, 1360; doi:10.3390/jcm9051360
2019
Tissue Cytokine IL-33 Modulates the Cytotoxic CD8 T Lymphocyte Activity During Nutrient Deprivation by Regulation of Lineage-Specific Differentiation Programs. Frontiers Immunology. 2019 Jul 24;10:1698. doi: 10.3389/fimmu.2019.01698
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase. Oncogene. 2019 Jun;38(24):4788-4803. doi: 10.1038/s41388-019-0758-x.
Sphingosine Kinase 2 Is a Negative Regulator of Inflammatory Macrophage Activation. Biochim Biophys Acta Mol Cell Biol Lipids . 2019 Sep;1864(9):1235-1246. doi: 10.1016/j.bbalip.2019.05.008.
A Comprehensive Assessment of Apigenin as an Antiproliferative, Proapoptotic, Antiangiogenic and Immunomodulatory Phytocompound. Nutrients. 2019 Apr 16;11(4):858. doi: 10.3390/nu11040858.
Betulin Silver Nanoparticles Qualify as Efficient Antimelanoma Agents in in Vitro and in Vivo Studies. European Journal of Pharmaceutics and Biopharmaceutics. 2019 Jan;134:1-19. doi: 10.1016/j.ejpb.2018.11.006.
2018
Botanical Therapeutics: Phytochemical Screening and Biological Assessment of Chamomile, Parsley and Celery Extracts against A375 Human Melanoma and Dendritic Cells. International Journal of Molecular Science 2018, 19(11), 3624; https://doi.org/10.3390/ijms19113624
NoxO1 Controls Proliferation of Colon Epithelial Cells. Frontiers in Immunology 05/2018; 9;973, DOI:10.3389/fimmu.2018.00973
Biglycan, a novel trigger of Th1 and Th17 cell recruitment into the kidney. Matrix Biology, 15 December 2017. pii: S0945-053X(17)30427-4. doi: 10.1016/j.matbio.2017.12.002. [Epub ahead of print]
Immunopharmacological activity of betulin in inflammation-associated carcinogenesis. Anticancer Agents Medicinal Chemistry 2017 Oct 12. doi: 10.2174/1871520617666171012124820.[Epub ahead of print] (Review)
2017
Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells. Mediators of Inflammation, December 2017(2):1-10 DOI10.1155/2017/5187368 [Epub ahead of print]
Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. Frontiers in Immunology 2017 Sep 29;8:1242. doi: 10.3389/fimmu.2017.01242. eCollection 2017., DOI: 10.3389/fimmu.2017.01242
Management of inflammatory bowel disease-related anemia and iron deficiency with specific reference to the role of intravenous iron in current practice. Expert Opinion Pharmacotherapy 2017 Nov;18(16):1721-1737. doi: 10.1080/14656566.2017.1391790. Epub 2017 Nov 5. (Review)
Letter: the importance of dosing and baseline haemoglobin when establishing the relative efficacy of intravenous iron therapies-authors' reply. Alimentary Pharmacology and Therapeutics 2017 Oct;46(7):705-706. doi: 10.1111/apt.14269.
Letter: inconsistency in reporting of hypophosphataemia after intravenous iron-authors' reply. Alimentary Pharmacology and Therapeutics 2017 Sep;46(6):643-644. doi: 10.1111/apt.14254.
Editorial: which iron preparation for patients with IBD? Authors' reply. Alimentary Pharmacology and Therapeutics 2017 Jul;46(2):195-196. doi: 10.1111/apt.14126.
Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cellular and Molecular Life Sciences 2017 Aug;74(16):3039-3055. doi: 10.1007/s00018-017-2518-9. Epub 2017 Apr 12.
Systematic review with network meta-analysis: comparative efficacy and tolerability of different intravenous iron formulations for the treatment of iron deficiency anaemia in patients with inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 2017 May;45(10):1303-1318., DOI:10.1111/apt.14043 (Review) 
Defective IL-23/IL-17 Axis Protects p47phox−/− Mice from Colon Cancer. Frontiers in Immunology 01/2017; 8(44)., DOI:10.3389/fimmu.2017.00044
Current evaluation and management of anemia in patients with inflammatory bowel disease. Expert Review of Gastroenterology and Hepatology 01/2017; 11(1)., DOI:10.1080/17474124.2017.1263566 (Review)
2016
High thioredoxin-1 levels in rheumatoid arthritis patients diminish binding and signalling of the monoclonal antibody Tregalizumab. Clinical Translational Immunology. 12/2016; 5(12):e121., DOI:10.1038/cti.2016.69
Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab. Frontiers in Pharmacology 12/2016; 7(7):412-412., DOI:10.3389/fphar.2016.00412
Activation-Induced Cell Death of Dendritic Cells Is Dependent on Sphingosine Kinase 1. Frontiers in Pharmacology 04/2016; 94((Suppl.))., DOI:10.3389/fphar.2016.00094
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. European Journal of Immunology 04/2016; 46(4):941-51., DOI:10.1002/eji.201545805
Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling. Journal of Crohn s and Colitis 02/2016; 10(8):jjw056., DOI:10.1093/ecco-jcc/jjw056
High plasma sST2 levels in gastric cancer and their association with metastatic disease. Cancer biomarkers: section A of Disease markers 01/2016; 16(1):117-125., DOI:10.3233/CBM-150547
2015
Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis. Scandinavian Journal of Immunology 2015 Sep;82(3):269-74. DOI:10.1111/sji.12317.
MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer. Oncotarget 03/2015; 6(12)., DOI:10.18632/oncotarget.3581
Simultaneous and Dose Dependent Melanoma Cytotoxic and Immune Stimulatory Activity of Betulin. PLoS ONE 03/2015; 10(3-3):e0118802., DOI:10.1371/journal.pone.0118802
Behaviour of four different B16 murine melanoma cell sublines: C57BL/6J skin. International Journal of Experimental Pathology 02/2015; 96(2). DOI:10.1111/iep.12114
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells – another aspect of Fingolimod action relevant for therapeutic application. Biological Chemistry 01/2015; DOI:10.1515/hsz-2014-0287
A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunology and Cell Biology 2015 Apr;93(4):396-405. doi: 10.1038/icb.2014.102
Immunomodulatory effects of 25-hydroxyvitamin D3 on monocytic cell differentiation and influence of vitamin D3 polymorphisms in type 1 diabetes. The Journal of Steroid Biochemistry and Molecular Biology 2015 Mar;147:17-23. doi: 10.1016/j.jsbmb.2014.11.001
2014
Modulation of IL-33/ST2-TIR and TLR Signalling Pathway by Fingolimod and Analogues in Immune Cells. Scandinavian Journal of Immunology 09/2014; 80(6). DOI:10.1111/sji.12238
Sphingosine-1-Phosphate Modulates Dendritic Cell Function: Focus on Non-Migratory Effects in Vitro and in Vivo. Cellular Physiology and Biochemistry 06/2014; 34(1):27-44., DOI:10.1159/000362982 (Review)
Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations. Stem cells and development 03/2014; 23(7):755-66., DOI:10.1089/scd.2013.0335
2013
A characterization of four B16 murine melanoma cell sublines molecular fingerprint and proliferation behavior. Cancer Cell International 07/2013; 13(1):75., DOI:10.1186/1475-2867-13-75
Response to Comment on "CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation". The Journal of Immunology 07/2013; 191(2):525-6., DOI:10.4049/jimmunol.1390037 (Comment)
High Serum Levels of the Interleukin-33 Receptor Soluble ST2 as a Negative Prognostic Factor in Hepatocellular Carcinoma. Translational oncology 06/2013; 6(3):311-8., DOI:10.1016/S0168-8278(13)60632-7
CXCL9 Causes Heterologous Desensitization of CXCL12-Mediated Memory T Lymphocyte Activation. The Journal of Immunology 02/2013; 190(7)., DOI:10.4049/jimmunol.1101293
A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity. Antimicrobial Agents and Chemotherapy 2013 Feb;57(2):679-88. DOI: 10.1128/AAC.01152-12
2012
Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P2 Receptor Subtype. PLoS ONE 11/2012; 7(11):e49427., DOI:10.1371/journal.pone.0049427
LC-MS/MS determination of FTY720 and FTY720-phosphate in murine intracellular compartments and human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 03/2012; 887-888:122-7., DOI:10.1016/j.jchromb.2012.01.023
Selective Glucocorticoid Receptor Agonists for the Treatment of Inflammatory Bowel Disease: Studies in Mice with Acute Trinitrobenzene Sulfonic Acid Colitis. Journal of Pharmacology and Experimental Therapeutics 01/2012; 341(1):68-80., *) two authors contributed equally. DOI:10.1124/jpet.111.183947
2011
Serum MicroRNA-21 as Marker for Necroinflammation in Hepatitis C Patients with and without Hepatocellular Carcinoma. PLoS ONE 10/2011; 6(10):e26971., DOI:10.1371/journal.pone.0026971
Serum miR-122 as a Biomarker of Necroinflammation in Patients With Chronic Hepatitis C Virus Infection. The American Journal of Gastroenterology 05/2011; 106(9):1663-9., DOI:10.1038/ajg.2011.161
The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Molecular Immunology 03/2011; 48(9-10):1139-48., DOI:10.1016/j.molimm.2011.02.007